产品货号：
Z17586
中文名称：
HAP1抗体
英文名称：
Anti-HAP1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HAP1 Antibody |
| 指标别名 | HAP 1;HAP1;HAP2;hHLP1;HIP5;HLP;HLP1;Neuroan 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | HAP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | HAP1 antibody was raised against a 19 amino acid synthetic peptide from near the center of human HAP1.The immunogen is located within amino acids 310 - 360 of HAP1. |
| 计算分子量 | 76kDa |
| 成分 | HAP1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | HAP1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Huntington's disease (HD),a neurodegenerative disorder characterized by loss of striatal neurons,is caused by an expansion of a polyglutamine tract in the HD protein huntingtin.HAP1 was initially identified through a two-hybrid library screening;the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract.HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1),suggesting that HAP1 may play a role in vesicular trafficking or organelle transport.HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles.Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity,which suggests that loss of this function might contribute to pathogenesis.Several alternatively spliced isoforms have been described for HAP1. |
| Uniprot ID | P54257 |
| 基因名全称 | Huntingtin-associated protein 1 |
| 蛋白名全称 | Huntingtin-associated protein 1 |
| 推荐稀释比 | HAP1 antibody can be used for detection of HAP1 by Western blot at 0.5 ～ 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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